Diabetes
“The health-relevant functionality of Mucuna pruriens (Fava Bean) was improved by priming the seeds with elicitors of the pentose phosphate pathway (PPP) such as fish protein hydrolysates (FPHs), lactoferrin (LF) and oregano extract (OE) followed by dark germination. FPH elicited the highest phenolic content of 19 mg/g FW on day 1, which was 38% higher than control sprouts. OE enhanced Parkinson’s disease-relevant L-DOPA content by 33% on day 1 compared to control sprouts. Anti-diabetes-relevant alpha-amylase inhibition percent (AIP) and alpha-glucosidase inhibition percent (GIP) were high in the cotyledons and decreased following elicitation and sprouting. For potential anti-diabetic applications, low AIP and high GIP with moderate L-DOPA content on day 4 of dark germination could be optimal. Improved L-DOPA concentrations in a soluble phenolic and antioxidant-rich M. pruriens background on day 1 sprouts have potential for Parkinson’s disease management.”
Improved health-relevant functionality in dark germinated Mucuna pruriens (Fava Bean) sprouts by elicitation with peptide and phytochemical elicitors.
Bioresour Technol. 2009 Oct;100(19):4507-14. Epub 2009 May 19 Randhir R, Kwon YI, Shetty K.
“The anti-diabetic effects of Mung bean sprout (MBS) extracts and Mung bean seed coat (MBSC) extracts were investigated in type 2 diabetic mice. Male KK-A (y) mice and C57BL/6 mice were used in this study. In KK-A (y) mice, the blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and blood urea nitrogen (BUN) levels were significantly higher than those in the C57BL/6 mice ( P < 0.001, P < 0.001, P < 0.01, P < 0.001, P < 0.01, and P < 0.01). In addition, KK-A (y) mice showed an obvious decrease in insulin immunoreactivity in pancreas as well. MBS and MBSC were orally administrated to KK-A (y) mice for 5 weeks. It was found that MBS (2 g/kg) and MBSC (3 g/kg) lowered blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and BUN levels and at the same time markedly imporved glucose tolerance and increased insulin immunoreactive levels. These results suggest that MBS and MBSC exert an antidiabetic effect in type 2 diabetic mice. “
Antidiabetic activity of Mung bean extracts in diabetic KK-Ay mice.
J Agric Food Chem. 2008 Oct 8;56(19):8869-73. Epub 2008 Sep 4
Yao Y, Chen F, Wang M, Wang J, Ren G.
“The study findings show that sulforaphane, a chemical in broccoli, switches on a set of antioxidant genes and enzymes in specific immune cells, which then combat the injurious effects of molecules known as free radicals that can damage cells and lead to disease.
….
A dynamic equilibrium exists in the body between the mechanisms that lead to increased free radical production and those antioxidant pathways that help combat free radicals. The delicate balance between pro-oxidant and antioxidant forces in the body could determine the outcome of many disease processes that are associated with aging, including cardiovascular disease, degenerative joint diseases and diabetes, as well as the decline in efficiency of the immune system’s ability to protect against infectious agents.
….
“We found that treating older mice with sulforaphane increased the immune response to the level of younger mice,” said Hyon-Jeen Kim, first author and research scientist at the Geffen School.
UCLA Newsroom
March 5, 2008
Study finds that broccoli may help boost the aging immune system
Champeau, Rachel
http://www.newsroom.ucla.edu/portal/ucla/ucla-study-reports-broccoli-may-46578.aspx
