Retinal Damage

“Thioredoxin (Trx) is a multifunctional endogenous redox regulator that protects cells against various types of cellular or tissue stresses. This study was conducted to test whether sulforaphane (SF), a naturally occurring isothiocyanate that is highly concentrated in broccoli sprouts, induces Trx in retinal tissues and whether pretreatment with SF protects against light-induced retinal damage in mice.

Sulforaphane induced Trx in murine retina and effectively reduced retinal light damage. Evidence suggests that the ARE is involved in the mechanism of Trx induction by SF in RPE cells.”


Investigative Opthamology and Visual Science
March 2005 vol. 46 no. 3979-987

Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice
Masaki Tanito, Hiroshi Masutani, Yong-Chul Kim, Mai Nishikawa, Akihiro Ohira, Junji Yodoi