“ We hypothesized that intake of dietary phase 2 protein inducers would ameliorate both hypertension and atherosclerotic changes in the spontaneously hypertensive stroke-prone rat. For 5 days/week for 14 weeks, we fed rats 200 mg/day of dried broccoli sprouts that contained glucoraphanin, which is metabolized into the phase 2 protein-inducer sulforaphane (Group A), sprouts in which most of the glucoraphanin was destroyed (Group B), or no sprouts (Group C). After 14 weeks of treatment, no significant differences were seen between rats in Groups B and C. Rats in Group A had significantly decreased oxidative stress in cardiovascular and kidney tissues….. We conclude that a diet containing phase 2 protein inducers (sulforaphane) also reduces the risk of developing cardiovascular problems of hypertension and atherosclerosis.”
Proceedings of the National Academy of Sciences of the United States of America
March 22, 2004
Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system
Lingyun Wu , M. Hossein Noyan Ashraf , Marina Facci , Rui Wang , Phyllis G. Paterson, Alison Ferrie, Bernhard H. J. Juurlink